Out-of-hospital Hypertonic Resuscitation After Traumatic Hypovolemic Shock

Hypovolemic shock resuscitation.

Several changes in the way patients with hemorrhagic shock are resuscitated have occurred over the past decades, including permissive hypotension, minimal crystalloid resuscitation, earlier blood transfusion, and higher plasma and platelet-to-red cell ratios. Hemostatic adjuncts, such as tranexamic acid and prothrombin complex, and the use of new methods of assessing coagulopathy are also being...

Hypovolemic shock and resuscitation.

Hypovolemic shock is the manifestation of hypoperfusion from inadequate intravascular volume resulting in cellular hypoxia. Early, effective treatment tailored to the individual patient will minimize morbidity and mortality. The causes and end-organ responses can differ with each patient, requiring an understanding of the underlying physiology and pathophysiology. Treatment always consists of o...

Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial.

BACKGROUND The leading cause of late mortality after trauma is multiple organ failure syndrome, due to a dysfunctional inflammatory response early after injury. Preclinical studies demonstrate that hypertonicity alters the activation of inflammatory cells, leading to reduction in organ injury. The purpose of this study was to evaluate the effect of hypertonicity on organ injury after blunt trau...

Hypovolemic Shock after Circumcision

Circumcision has been the most frequently applied surgical procedure since ancient times [1,2]. In Turkey, the application of this surgical procedure continues due to traditional and religious reasons. Iron deficiency anemia (IDA) is a common pediatric problem affecting up to 25% of all the children worldwide [3].Even though circumcision is known to be a procedure with minor complications, it c...

ROC Hypertonic Saline Trial Title: Hypertonic Resuscitation following Traumatic Injury